Author/Editor     Beović, B; Mrhar, A; Karba, R; Zupančič, T; Grabnar, I; Belič, A; Marolt-Gomišček, M
Title     Influence of fever on cefazolin pharmacokinetics
Type     članek
Source     J Chemother
Vol. and No.     Letnik 11, št. 1
Publication year     1999
Volume     str. 40-5
Language     eng
Abstract     The influence of fever on the pharmacokinetics of cefazolin was investigated in patients with acute febrile diseases. Nine patients were included in the study. Antibiotic serum concentrations were determined using high performance liquid chromatograpy (HPLC). An analog computer and the SIMULINK software package were used to identify the pharmacokinetic model and PCNONLIN software package to obtain the secondary parameters. In 6 patients a two-compartment pharmacokinetic model of cefazolin was observed during fever and after defervescence. In 2 patients a two-compartment model changed to a one-compartment after defervescence, and a one-compartment model was observed in one patient during both periods. Cefazolin-treated patients with a two-compartment model (6/9) had higher Cmax, mean steady state serum concentrations (Css), and area under the plasma centration-time curve (AUC(0-->infinity)), smaller central compartment volume (V1), and lower clearance (Cl) during fever. The varying distribution of antibiotics during fever probably reflects different hemodynamic responses to fever.
Descriptors     CEFAZOLIN
CEPHALOSPORINS
FEVER
SEX FACTORS
AGE FACTORS
AREA UNDER CURVE
COMPUTER SIMULATION
MODELS, CHEMICAL
PROSPECTIVE STUDIES