Author/Editor		Beović, Bojana; Mrhar, Aleš; Karba, Rihard; Župančič, Tatjana; Grabnar, Iztok; Belič, Aleš; Marolt-Gomišček, Marica
Title		Influence of fever on the pharmacokinetics of ciprofloxacin
Type		članek
Source		Int J Antimicrob Agents
Vol. and No.		Letnik 11, št. 1
Publication year		1999
Volume		str. 81-5
Language		eng
Abstract		The influence of fever on the pharmacokinetics of ciprofloxacin was investigated in seven patients with acute febrile diseases. Antibiotic serum concentrations were determined using high-performance liquid chromatograpy (HPLC). The analog computer and the Simulink software package were used to identify the pharmacokinetic model and Penoclin software package to obtain the secondary parameters. During fever, higher maximum serum concentrations (Cmax) of ciprofloxacin were observed in six out of seven patients. The result suggests that the influence of fever on the pharmacodynamics of ciprofloxacin is favorable.
Descriptors		ANTIBIOTICS CIPROFLOXACIN FEVER PYELONEPHRITIS SEX FACTORS AGE FACTORS