Author/Editor		Korošec, Marko
Title		Interakcije mežikanja in vidnega sledenja pri zdravih in ljudeh s Parkinsonovo boleznijo
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2006
Volume		str. 67
Language		slo
Abstract		Background. Smooth pursuit requires uninterrupted vision and eye movement signals to keep the fovea locked-on to the moving target. Blinking necessary to maintain the corneal tear film, however, disturbs the execution of smooth pursuit. Blinks transiently interrupt vision and produce blink-associated eye movements (the eye-globe rotates nasally, downward, outward and makes a slight displacement into the orbit). With this, blinks can change the accuracy and velocity of smooth pursuit eye movements. To avoid this conflict, the nervous system reduces the rate of spontaneous blinking during visual tracking tasks. These interactions between blinking and smooth pursuit could be coordinated by a separate group of neurons (a 'coordination center'). Study of patients with various neurological disorders of known pathology, such as Parkinson's disease (PD), can potentially help to better understand the interaction between blinking and smooth pursuit. Objectives. To investigate the interaction of blinks and smooth pursuit eye movements in healthy subjects and patients with PD. Based on spontaneous, voluntary and reflex blink kinematics, spontaneous blink rate before, during and after short periods of smooth tracking and examining the influence of reflex blinks on maintenance and initiation of smooth pursuit eye movements, we tried to determine whether there is evidence for a center in the nervous system that coordinates blinking and smooth pursuit. Comparing the results of PD patients with those of healthy subjects we also tried to determine the influence of nigrostriatal system on blink-smooth pursuit interactions. (Abstract truncated at 2000 characters)
Descriptors		PARKINSON DISEASE BLINKING EYE MOVEMENTS PURSUIT, SMOOTH ELECTROMYOGRAPHY ANTIPARKINSON AGENTS