Author/Editor		Fuerst, Jurij; Peklar, Jure; Samaluk, Vita
Title		Poraba anksiolitikov ter hipnotikov in sedativov v Sloveniji
Translated title		Use of anxiolytics, hypnotics and sedatives in Slovenia
Type		članek
Source		Zdrav Vars
Vol. and No.		Letnik 45, št. 3
Publication year		2006
Volume		str. 150-7
Language		slo
Abstract		Background: Overprescribing of some psychoactive drugs can lead to tolerance, dependence and abuse. The purpose of this paper is to address the use of anxiolytics and hypnotics/sedatives in Slovenia, to compare the situation with that in some other countries and to highlight the most interesting findings. Methods: Data for all prescriptions of anxiolytics and hypnotics/sedatives in Slovenia during the period 2000 2004 were derived from the national Institute for Public Health and Health Insurance Institute prescription database. The results were presented as defined daily doses (DDD) per 1000 inhabitants per day. Results: Between 2000 and 2004 the use of anxiolytics decreased by 8 %, while the use of hypnotics increased by 22 %. The prevalence of use of anxiolytics is higher in women and increases with age. A significant regional variation in the use of both drug groups has been found: the difference between the region with the highest and that with the lowest frequency of use was 100 % for anxiolytics and 60 % for hypnotics/sedatives. There were even larger differences between regions concerning the use of high doses of diazepam and bromazepam, suggestive of potential abuse. Potentially excessive drug prescribing in elder patients is suggested by the observed multiple drug prescribing and simultaneous use of benzodiazepines and drugs to treat dementia. Compared to the four Scandinavian countries, Slovenia showed a lower prevalence of hypnotic use and a higher frequency of the use of anxiolytic drugs, but a lower overall frequency of use of both groups of drugs. Conclusions: Total prevalence of anxiolytic and hypnotic use in Slovenia has been found to be lower than in Scandinavian countries, yet further efforts, prompted by wide regional variations, are needed to curb the present drug use.
Summary		Izhodišča: Čezmerno predpisovanje nekaterih psihoaktivnih zdravil lahko vodi v razvoj tolerance in zasvojenosti, možne pa so tudi zlorabe. Namen prispevka je prikazati porabo anksiolitikov ter hipnotikov/sedativov v Sloveniji, jo umestiti v mednarodni okvir in opozoriti na nekatere izstopajoče podatke. Metode: Podatke o porabi anksiolitikov in hipnotikovlsedativov iz baze receptov Inštituta za varovanje zdravja in Zavoda za zdravstveno zavarovanje Slovenije smo prikazali v definiranih dnevnih odmerkih na 1000 prebivalcev na dan za obdobje 2000-2004. Rezultati: Medtem ko je poraba anksiolitikov v obdobju 2000-2004 upadla za 8 %, je poraba hipnotikov in sedativov v istem obdobju porasla za 22 %. Poraba anksiolitikov s starostjo močno narašča, ženske jih prejmejo več kot moški. Izrazite so regijske razlike v porabi obeh skupin zdravil. Medtem ko je razlika v porabi anksiolitikov med regijama z najnižjo in najvišjo porabo 100 %, je razlika v porabi hipnotikov in sedativov 60 %. Poraba najvišjih odmerkov diazepama in bromazepama, ki je lahko odsev zlorab, kaže na še večje regijske razlike. Predpisovanje zdravil starejšim bolnikom je preobsežno. Pogosto je kombiniranje anksiolitikov z antidementivi, ki je strokovno vprašljivo. Primerjava s skandinavskimi državami pokaže v Sloveniji sicer višjo porabo anksiolitikov, vendar bistveno nižjo porabo hipnotikov, tako da je skupna slovenska poraba najnižja v skupini primerjanih držav Zaključki: Glede na primerjavo s skandinavskimi državami je slovenska poraba anksiolitikov in hipnotikovlsedativov nižja, vendar bi jo bilo smiselno, glede na velike regijske razlike, tudi možno še bolj znižati.
Descriptors		DRUG UTILIZATION ANTI-ANXIETY AGENTS HYPNOTICS AND SEDATIVES DIAZEPAM BROMAZEPAM SLOVENIA