Author/Editor		Strgar-Hladnik, Mihaela
Title		Migrena in depresija
Translated title		Migraine and depression
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 45, št. Suppl 1
Publication year		2006
Volume		str. 23-6
Language		slo
Abstract		Migraine is a common disorder, with an estimated prevalence of 12% among adult population. The prevalence of migraine varies with gender and age, peaking between the ages of 35 to 45 years. Migraine is considered a neurological disorder, in which both vascular and neuronal components play a pathophysiological role. Various symptoms and signs may precede, accompany or follow the attacks of headache, thus determining different types of migraine as independent entities. Migraine is associated with a number of neurologic and psychiatric disorders, including stroke, epilepsy, depression, and anxiety disorders. Comorbidities present physicians with opportunities and challenges for both diagnosis and treatment. Therapeutic strategies may need to be modified to avoid potential drug interaction. Comorbidities may also provide clues to the pathophysiologies and any shared mechanisms of the two disorders. Longitudinal studies have demonstrated an interaction between migraine and major depression. Amitryptilline has been more frequently studied than other agents and is the only antidepressant with a fairly consistent support for efficacy in both migraine and depression treatment.
Summary		Migrena je pogosta oblika glavobola, ki se pojavlja v 12 % odrasle populacije. Pogostnost migrene se spreminja s spolom in z leti, največja je med 35. in 45. letom. Migreno preučujejo kot nevrološko motnjo, v katere patofiziologiji igrata vlogo tako žilna kot nevrološka komponenta. Pred napadi migrenskega glavobola ali ob njih lahko nastopijo različni simptomi in znaki, ki določajo različne oblike migrene kot samostojne entitete. Migreno povezujejo s številnimi nevrološkimi in psihiatričnimi boleznimi, vključno z možgansko kapjo, epilepsijo, depresijo in anksioznimi motnjami. Sočasen pojav druge bolezni zastavlja zdravniku nalogo, da po skupni diagnozi poišče še morebitno skupno zdravljenje. Strategijo zdravljenja je treba prilagoditi, da se izognemo morebitnim interakcijam med zdravili. Sočasnost bolezni lahko razkrije ključ do patofiziologije in pojasni morebiten skupni mehanizem obeh bolezni. Longitudinalne študije so pokazale na medsebojni vpliv med migreno in veliko depresijo. Amitriptilin so pogosteje raziskovali kot druga zdravila in je edini antidepresiv, ki se je dokazano jasno izkazal za učinkovitega pri zdravljenju obeh bolezni, migrene in depresije.
Descriptors		MIGRAINE DEPRESSION