Author/Editor		Poredoš, Pavel; Poredoš, Peter; Visnovič-Poredoš, Aleksandra
Title		Pomen odkrivanja predkliničnih oblik ateroskleroze
Translated title		The significance of detection of preclinical atherosclerosis
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 75, št. 8
Publication year		2006
Volume		str. 475-81
Language		slo
Abstract		Background Atherosclerosis is a chronic disease, which can go on for many decades with no clinically noticable changes. When clinical symptoms appear, the disease has usually already significantly progressed. There is currently no effective treatment for atherosclerosis. The disease can only be prevented. This is why it is important to detect it in its early stages, when preventive measures are the most effective. Today, with a help of non-invasive investition methods, mostly ultrasound based, we can detect changes in the structure and function of artery wall, which are typical for the early stages of atherosclerosis or predict disease course. Conclusions Such changes are: lower capability of artery expansion during an increased blood flow (endothelial dysfunction), intima-media thickening, artery walls, artery calcination and ankle-brachial index decrease. The research showed that these symptoms of preclinical atherosclerosis are tightly connected to authenticity of the risk factors, their number and duration, and that there is a tight connection between the general cardiovascular danger and the manifestation of preclinical and morphological changes of an artery wall. (Abstract truncated at 2000 characters)
Summary		Izhodišča Ateroskleroza je kronična bolezen, ki več let ali desetletij poteka brez klinično zaznavnih sprememb. Ob pojavu kliničnih znakov je bolezen običajno že močno napredovala. Zaenkrat še ne poznamo učinkovitega zdravljenja ateroskleroze. Bolezen lahko le preprečujemo. Zato je pomembno, da jo odkrijemo v najzgodnejšem obdobju, ko so preventivni ukrepi najučinkovitejši. Danes lahko s pomočjo neinvazivnih preiskavnih metod, zlasti ultrazvočnih, odkrivamo spremembe v sestavi in delovanju arterijske stene, ki so značilne za zgodnje obdobje ateroskleroze, ali pa napovedujejo njen razvoj. Med takšne spremembe sodijo: zmanjšana sposobnost razširitve arterije med povečanjem krvnega obtoka (endotelna disfunkcija), zadebelitev intime in medije arterijske stene, kalcinacije arterij in zmanjšanje gleženjskega indeksa. (Izvleček skrajšan na 2000 znakov)
Descriptors		ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR TUNICA INTIMA TUNICA MEDIA CAROTID ARTERIES RISK FACTORS BLOOD PRESSURE BRACHIAL ARTERY CALCINOSIS VASCULAR DISEASES