Author/Editor | Sollner-Dolenc, M; Crnošija, J; Simčič, S; Wraber, B; Pečar, S | |
Title | Influence of desmuramylpeptides from LK-409 series on the cytokine production in the mouse spleen cells | |
Type | članek | |
Source | Pharmazie | |
Vol. and No. | Letnik 61, št. 10 | |
Publication year | 2006 | |
Volume | str. 866-8 | |
Language | eng | |
Abstract | LK-409 (7-oxooctanoyl-L-Ala-D-iGln) was found to modulate immune response. To study the impact of minimal structural changes in the LK-409 molecule on the immunomodulatory activity a series of LK-409 analogues was prepared and their activities were evaluated. After the treatment of NmRI mice at a dose of 25 micro g daily for three consecutive days the isolated spleen cells were stimulated with concanavaline A and phorbol 12-myristate 13-acetate (PMA) or ionomycin and PMA, and the production of IL-2, IL-4,-IL-6, IL-10 and IFN-gamma studied as a function of the different LK-409 analogues. All the compounds modulate the Th1 /Th2 cytokine response, especially in the presence of ConA&PMA activation. The minimal structure modification of LK-409 strongly influences the regulation of the cytokine production. | |
Descriptors | SPLEEN ACETYLMURAMYL-ALANYL-ISOGLUTAMINE CYTOKINES INTERLEUKIN-1 INTERLEUKIN-4 MICE INTERLEUKIN-6 INTERLEUKIN-10 CELLS, CULTURED |