Author/Editor     Holm, Cecilia; Osterlund, Torben; Laurell, Henrik; Contreras, Juan Antonio
Title     Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
Type     članek
Source     Annu Rev Nutr
Vol. and No.     Letnik 20
Publication year     2000
Volume     str. 365-93
Language     eng
Abstract     Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a pivotal role in lipid metabolism, overall energy homeostasis, and, presumably, cellular events involving fatty acid signaling. Detailed knowledge about its structure and regulation may provide information regarding the pathogenesis of such human diseases as obesity and diabetes and may generate concepts for new treatments of these diseases. The current review summarizes the recent advances with regard to hormone-sensitive lipase structure and molecular mechanisms involved in regulating its activity and lipolysis in general. A summary of the current knowledge regarding regulation of expression, potential involvement in lipid disorders, and role in tissues other than adipose tissue is also provided.
Descriptors     ADIPOSE TISSUE
AMINO ACID SEQUENCE
CHOLESTEROL ESTERASE
CHROMOSOME MAPPING
HYPERLIPIDEMIA, FAMILIAL COMBINED
LIPOLYSIS
MODELS, CHEMICAL
MODELS, MOLECULAR
NEOPLASMS
OBESITY