Author/Editor		Derganc, M; Lazar, I
Title		Oligoelementi in vitamini pri kritično bolnih otrocih
Translated title		Trace elements and vitamins in critically ill children
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 13, št. Suppl 1
Publication year		2006
Volume		str. 32-7
Language		eng
Abstract		As oxidative stress plays a central role in the pathophysiology of critical illness, the authors focus on antioxidant vitamins and trace elements, which participate in the defence against oxidative stress in critically ill children: vitamins C, E and beta-carotene and selenium. zinc, copper and manganese. The most important is selenium, a cofactor for the central antioxidant enzyme glutathione peroxidase, alone or in combination with other antioxidants. Most data are derived from studies in critically ill adults and paediatric data from neonates and children with severe burns. The recent development of sophisticated new laboratory methods for determining deficiencies of vitamins and trace elements and the availability of new intravenous preparations of selenium and zine also enable their rationaf use in critically ill children.
Summary		Oksidativni stres je eden temeljnih dejavnikov v patotiziologiji pri kritično bolnih, zato se v prispevku osredotočava predvsem na antioksidatne vitamine in oligoelemente, ki sodelujejo v obrambi pred tem stresom, in sicer na vitamine C. E in beta-karoten ter selen. cink, baker in mangan. Osrednjo vlogo igra selen kot kofaktor najvažnejšega antioksidantskega encima glutationske peroksidaze sam ali v kombinaciji z drugimi antioksidanti. Večina izsledkov sloni na večjih študijah kritično bolnih odraslih, pri otrocih pa predvsem na študijah novorojenčkov in hudo opečenih otrok. Razvoj novih biokemičnih metod za ugotavljanje pomanjkanja omenjenih vitaminov in oligoelementov ter dostopnost novih intravenskih pripravkov selena in cinka odpirata možnosti za njihovo racionalno uporabo tudi pri kritično bolnih otrocih.
Descriptors		CRITICAL ILLNESS OXIDATIVE STRESS ANTIOXIDANTS VITAMINS TRACE ELEMENTS ASCORBIC ACID VITAMIN E BETA CAROTENE SELENIUM ZINC COPPER MANGANESE