Author/Editor     Luzar, Boštjan; Gašljević, Gorana; Jurčić, Vesna; Bračko, Matej
Title     Hemosiderotic fibrohistiocytic lipomatous lesion: early pleomorphic hyalinizing angiectatic tumor?
Type     članek
Source     Pathol Int
Vol. and No.     Letnik 56, št. 5
Publication year     2006
Volume     str. 283-6
Language     eng
Abstract     Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) and early pleomorphic hyalinizing angiectatic tumor (PHAT) are characterized histologically by an admixture of fat, moderately cellular fascicles of hemosiderin-laden spindle cells growing in a perivascular, periadipocytic and septal pattern, as well as the presence of macrophages and chronic inflammatory cells. In contrast to a suggested reactive nature of HFLL, PHAT is regarded as a non-metastasizing tumor of uncertain lineage in the recent World Health Organization classification of soft tissue tumors. Reported herein is the case of a 47-year-old woman with an unencapsulated and irregularly circumscribed recurring lesion in the ankle/foot region that developed following ankle distortion and that fulfills histological criteria for both HFLL and early PHAT. In summary, the present case suggests a reactive over-neoplastic nature of HFLL and confirms profound histological similarities with early PHAT. Until more data become available on the biological potential of HFLL/early PHAT, radical surgical excision and follow up of the patient remains the best treatment option.
Descriptors     ANGIOFIBROMA
ANKLE
HEMOSIDERIN
HEMOSIDEROSIS
LIPIDS
LIPOMA
NEOPLASM RECURRENCE, LOCAL
SOFT TISSUE NEOPLASMS
TREATMENT OUTCOME
TUMOR MARKERS, BIOLOGICAL