Author/Editor		Lainščak, Mitja; Vrtovec, Bojan; Bunc, Matjaž; Doehner, Wolfram
Title		Metabolic disturbances in chronic heart failure: where to from here?
Translated title		Metabolične spremembe pri srčnem popuščanju: kako naprej?
Type		članek
Source		Slov Kardiol
Vol. and No.		Letnik 3, št. 2
Publication year		2006
Volume		str. 126-30
Language		eng
Abstract		Although chronic heart failure primarily affects the cardiovascular system, complex metabolic disturbances may ensue. Of those, glucose and uric acid metabolism, steroids, and imbalanced catabolism/anabolism processes still need to be intensively investigated. Metabolic disturbances are tightly associated with both symptomatic status and disease progression suggesting a pathopysiologic involvement. Despite relevant prevalence of metabolic disturbances in patients with chronic heart failure we have not yet established therapeutic approaches aiming at metabolic intervention. Results of the ongoing trials might contribute importantly to our clinical practice in the future.
Summary		Čeprav kronično srčno popuščanje primarno prizadene srčno-žilni sistem, se lahko pojavijo kompleksne motnje metabolizma. Metabolizem glukoze in sečne kisline, steroidni hormoni in neuravnoteženost med katabolizmom ter anabolizmom še vedno niso zadosti raziskani. Metabolične spremembe so tesno povezane tako s simptomi kot tudi z napredovanjem bolezni, kar kaže na patofiziološke povezave. Prevalenca metaboličnih motenj je pri bolnikih s kroničnim srčnim popuščanjem relativno visoka, vendar danes še ne poznamo ustreznih terapevtskih pristopov zanje. Trenutno poteka več kliničnih raziskav, ki bodo lahko pomembno vplivale na našo klinično prakso v prihodnosti.
Descriptors		HEART FAILURE, CONGESTIVE INSULIN RESISTANCE URIC ACID CACHEXIA