Author/Editor		Vrtovec, Bojan; Sever, Matjaž; Domanovič, Dragoslav; Ležaič, Luka; Černelč, Peter
Title		Stem cell therapy for advanced chronic heart failure
Translated title		Zdravljenje napredovalega srčnega popuščanja s presaditvijo matičnih celic
Type		članek
Source		Slov Kardiol
Vol. and No.		Letnik 3, št. 2
Publication year		2006
Volume		str. 138-42
Language		eng
Abstract		Cardiomyocyte necrosis leads to formation of akinetic fibrous scar tissue. Thus, an exogenous supply of cells with the property of forming contractile elements has been proposed as a potential treatment strategy to increase contractility and cardiac performance. Although several approaches to cellular therapy for the failing heart are under investigation, the use of autologous bone-marrow stem cells has gained the most widespread clinical acceptance. In our center we developed a bone marrow stem cell transplantation protocol that consists of three steps. First, bone marrow is stimulated with G-CSF to yield sufficient quantities of peripheral CD34 cells. Then, these cells are collected from peripheral blood via apheresis. Finally, the collected cells are administered via intracoronary route to the damaged areas of myocardium. Our first clinical experience is encouraging, with some evident stem cell therapyrelated improvements in clinical, echocardiographic and electrocardiographic parameters. By gaining additional experience in the future we hope to further improve the effectiveness of this therapeutic approach in patients with advanced heart failure.
Summary		Nekroza srčnomišičnih vlaken vodi do nastanka akinetične vezivne brazgotine. Krčljivost prizadetih predelov srčne mišice bi lahko bistevo izboljšali z vsaditvijo celic, ki imajo sposobnost tvoriti nova srčnomišična vlakna. Čeprav se v zadnjem času razvija več metod presaditve celic pri bolnikih s srčnim popuščanjem, je največ kliničnih izkušenj na voljo pri presaditvi avtolognih matičnih celic iz kostnega mozga. V Kliničnem centru v Ljubljani smo razvili protokol presaditve matičnih celic iz kostnega mozga, Ici potel<a v treh delih. Najprej spodbujamo kostni mozeg z G-CSF, kar povzroči večje izplavljanje CD34 matičnih celic v periferno kri. Nato matične celice iz periferne krvi zberemo z aferezo in jih s katetrom prek koronarne arterije vbrizgamo v prizadeto območje srčne mišice. Naši prvi rezultati s to metodo so vzpodbudni in kažejo na izboljšanje kliničnih, ultravočnih in elektrokardiografskih kazalcev. Upamo, da bomo metodo v prihodnje lahko še izpopolnili in tako zmanjšali obolevnost bolnikov z napredovalim srčnim popuščanjem.
Descriptors		HEART FAILURE, CONGESTIVE STEM CELLS MYOCARDIAL INFARCTION