Author/Editor		Novaković, Srdjan
Title		Molekularni mehanizmi nastanka raka - karcinogeneza
Translated title		Molecular mechanisms of carcinogenesis
Type		članek
Source		In: Gašperlin L, Žlender B, editors. Karcinogene in antikarcinogene komponente v živilih. 24. Bitenčevi živilski dnevi; 2006 nov 9-10; Ljubljana. Ljubljana: Biotehniška fakulteta, Oddelek za živilstvo,
Publication year		2006
Volume		str. 17-21
Language		slo
Abstract		Malignant transformation of the cell depends upon mutual activity of mutagenic factors - the initiators and non-mutagenic factors - the promotors. These factors in concert affect the expression of genes (most importantly the expression of regulatory genes), stimulate the proliferation of cells and promote the division of cells whose DNA is damaged. The carcinogenic agents can be chemical carcinogens, various viruses or different types of radiation as the UV light and ionizing radiation. Predominately two groups of genes are involved in the carcinogenic process - protooncogenes and tumor suppressor genes. Protooncogenes are in the process of caccinogenesis stimulated to high levels of expression while the expression of tumor suppressox genes is silenced or their products are funcrionally inactive. Also other factors are involved in the carcinogenesis that do not alter the nucleotide sequence and ue termed epigenetic factors.
Descriptors		NEOPLASMS CARCINOGENS PROTO-ONCOGENES GENES, SUPPRESSOR, TUMOR