Author/Editor		Kraigher, Alenka; Bregant, Lev
Title		BCG in nova cepiva proti tuberkulozi
Translated title		BCG and new vaccines against tuberculosis
Type		članek
Source		In: Felc Z, Ilijaš-Trofenik A, Bovha K, editors. Tuberkuloza pri nosečnici, novorojenčku in otroku. Krči pri novorojenčku in dojenčku. Zbornik predavanj 4. simpozij in učna delavnica z mednarodno udeležbo Na stičiščih neonatologije; 2006 nov 17-18; Laško. Celje: Splošna bolnišnica Celje,
Publication year		2006
Volume		str. 81-90
Language		slo
Abstract		Tuberculosis remains a major health threat, solved by neither chemotherapy nor vaccination is still considered an important strategy. BCG vaccination is still the subject of much controversy as to its effectiveness and applicability. BCG vaccination does not prevent transmission of infection to the individual. Although several new vaccine candidates will pass clinical trials within the next years, the most effective vaccination strategy will be to combine different vaccine candidates and to use a prime-boost approach. A successful vaccination regime must stimulate memory T cells and, at the same time, avoid exhaustion of memory and suppression by regulatory mechanisms. The most probable scenario is priming with one vaccine candidate followed by boosting with another vaccine candidate.
Descriptors		TUBERCULOSIS BCG VACCINE