Author/Editor		Poredoš, P; Kek-Ljubec, A; Poredoš, P; Visnovič-Poredoš, A
Title		Endothelial dysfunction predictor of structural changes of arterial wall in type I diabetes
Type		članek
Source		Int Angiol
Vol. and No.		Letnik 25, št. 3
Publication year		2006
Volume		str. 280-6
Language		eng
Abstract		AIM: We examined whether alteration in vascular endothelial function exists in non-insulin dependent diabetes mellitus (NIDDM) and whether impaired endothelium-dependent responses in those patients are associated with increased intima-media thickness (IMT), the time sequence of their appearance and the role of individual risk factors in development of structural deterioration of arterial wall. METHODS: Ultrasound technique was used to measure brachial artery flow mediated dilation (FMD) response and carotid IMT in 38 young adults with type I diabetes aged 22-34 years and 35 healthy controls aged 22-36 years. RESULTS: Patients had significantly lower FMD than controls (4.15/2.8/ vs 11.3/3.6/, P<0.0001) and was in all diabetic patients below the mean value of controls. Further, carotid intima-media was in insulin dependent diabetes mellitus (IDDM) patients significantly thicker than in healthy subjects (0.65/0.04 vs 0.56/0.04, P=0.0001) and was related to body mass and body mass index, to the age of patients, the duration of diabetes and several risk variables. In a multivariate model FMD was most significantly and independently associated to IMT. However, significant thickening of intima-media was observed only in patients with progressed deterioration of FMD and it appeared in those subjects with long-lasting disease. IMT was also influenced by urinary albumin excretion and low-density lipoprotein (LDL) cholesterol concentration. CONCLUSIONS: Endothelium dependent FMD response is impaired in IDDM and is associated with increased carotid artery IMT. Significant thickening of intima-media appears in patients with advanced deterioration of FMD that is related to the duration of the disease. These data suggest that advanced endothelial dysfunction in IDDM may predispose to development of morphologic atherosclerotic lesions of arterial wall.
Descriptors		ENDOTHELIUM, VASCULAR DIABETES MELLITUS, INSULIN-DEPENDENT BRACHIAL ARTERY CAROTID ARTERIES TUNICA INTIMA TUNICA MEDIA BODY MASS INDEX ALBUMINURIA LIPOPROTEINS, LDL CHOLESTEROL BLOOD FLOW VELOCITY RISK FACTORS ADULT