Author/Editor | Rener-Primec, Zvonka; Stare, Janez; Neubauer, David | |
Title | The risk of lower mental outcome in infantile spasms increases after three weeks of hypsarrhythimia duration | |
Type | članek | |
Source | Epilepsia | |
Vol. and No. | Letnik 47, št. 12 | |
Publication year | 2006 | |
Volume | str. 2202-5 | |
Language | eng | |
Abstract | To assess the correlation between hypsarrhythmia duration and mental outcome in infantile spasms (IS) the medical records of 48 infants with IS were reviewed retrospectively and psychological assessments undertaken at follow-up at the age of 3 to 13 years. We found 18 (38%) cryptogenic IS cases with typical hypsarrhythmia and 30 symptomatic with modified hypsarrhythmia-further classified into 15 cases as multifocal, 10 as pseudoperiodic and 5 as unilateral hypsarrhythmia. A short treatment lag (one to two weeks) occurred in 25, three to four weeks in 10 cases. Spasms ceased within one month after treatment in 23 infants. At follow-up 15 children had normal mental outcome (borderline included). A correlation between hypsarrhythmia duration longer than three weeks and lower mental outcome was found using the logistic regression model. The duration of hypsarrhythmia represents a sensitive prognostic parameter in IS; the risk of mental retardation increases after three weeks of hypsarrhythmia. | |
Descriptors | SPASMS, INFANTILE MENTAL RETARDATION INFANT CHILD FOLLOW-UP STUDIES |