Author/Editor		Božič, Borut; Čučnik, Saša; Kveder, Tanja; Rozman, Blaž
Title		Affinity and avidity of autoantibodies
Type		članek
Source		In: Shoenfeld Y, Gershwin ME, Meroni PL, editors. Autoantibodies. 2 ed. Boston: Elsevier,
Publication year		2007
Volume		str. 21-8
Language		eng
Abstract		The basic knowledge and clinical applications of the detection of affinity/avidity of autoantibodies are relatively scarce. Surprisingly, there have been very few recent studies concerning this topic. While theoretical thermodynamics of antigen-antibody interactions are well known, their practical use in detection or determination of autoantibodies is deficient. Both, affinity and specificity for antigens may have important impact for selection of the detection assay. The major problem may be attributed to the lack of suitable measuring methods according to the Law of Mass Action. Selective nonorgan-specific autoimmune disorders have been chosen to demonstrate the currently existing controversies. Nevertheless, some recent information including new methods and sophisticated technologies gives some hope for future usefulness.
Descriptors		AUTOANTIBODIES ANTIBODY AFFINITY AUTOIMMUNE DISEASES BINDING SITES, ANTIBODY ANTIGEN-ANTIBODY REACTIONS ARTHRITIS, RHEUMATOID LUPUS ERYTHEMATOSUS, SYSTEMIC ANTIPHOSPHOLIPID SYNDROME