Author/Editor		Puh, Urška
Title		Okrevanje motorične skorje in gibanja zgornjega uda v zgodnjem obdonju po možganski kapi
Translated title		Recovery of motor cortex and upper extremity movement during acute stage after stroke
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2006
Volume		str. 115
Language		slo
Abstract		The aim of the study was twofold: 1) to investigate the brain cortex activation characteristics in the first, and third week, and three months after stroke and 2) to establish the relationship between the recovery of primary motor cortex (M1) and motor functions of upper extremity. Methods: Twelve patients, aged 65 +- 15 years, where included in the study 2-8 days after stroke. All patients had impaired function of the upper extremity and were right-handed prior the stroke in either left (8 patients) or right (4 patients) hemisphere. Brain cortex activation, measured with functional magnetic resonance imaging, was compared with results of 13 healthy subjects, aged 41.5 +- 11 years. In stroke patients, recovery of upper extremity was evaluated by measurements of muscle strength, dexterity, functional skills, and performance of activities of daily living. Results: In comparison to healthy subjects, an attenuated activation of certain regions of interest in the ipsilesional or contralesional hemisphere was observed in stroke patients during hemiparetic extremity (HPE) performance in the first and third week after stroke. Only in the group of patients with stroke in the right hemisphere these differences persisted up to three months. Brain cortex activation was different also during performance with the nonhemiparetic extremity (NHPE). The observed difference between hemispheres in stroke patients gradually normalized with time, however the level of activation remained different from healthy subjects even three months after stroke. Concomitantly the movement characteristics of both upper extremities improved. In most cases, recovery of HPE correlated well with the intensity and/or area of activation of M1 in the ipsilesional, but only in some cases also with its activation in the contralesional hemisphere. More correlations were observed with dexterity than with muscle strength. (Abstract truncated at 2000 characters)
Descriptors		CEREBRAL INFARCTION MOTOR CORTEX ARM MOVEMENT MAGNETIC RESONANCE IMAGING MUSCLE CONTRACTION MOTOR SKILLS ACTIVITIES OF DAILY LIVING HEMIPLEGIA