| Author/Editor | Pretnar-Oblak, Janja | |
| Title | Možganskožilna odzivnost na L-arginin in endotelijsko odvisna vazodilatacija pri bolnikih z lakunarnimi infarkti | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2006 | |
| Volume | str. 76 | |
| Language | slo | |
| Abstract | Background and purpose: It is not clear from present studies weather endothelial function in patients with lacunar infarctions (LI) is impaired. Cerebrovascular reactivity to L-arginine by means of transcranial Doppler probably reflects function of cerebral endothelium. So far cerebrovascular reactivity to L-arginine has not been determined in patients with LI. Furthermore, there is no data about systemic endothelial impairment in these patients. In our study we used flow-mediated dilatation (FMD) and intima-media thickness (IMT) for evaluation of systemic endotelial impairment. It is possible that statine treatment improves endothelial function in patients with LI. In four consecutive studies we compared patients with LI, patients with similar risk factors (SR) and healthy volunteers. We tested (1) if cerebrovascular reactivity to L-arginine in patients with LI differs from those of the control groups; (2) if IMT and FMD differs in patients with LI compared to both control groups; (3) if cerebrovascular reactivity to L-arginine correlates with IMT and FMD in patients with LI; (4) if statine treatment improves cerebrovascular reactivity to L-arginine and FMD in patients with LI and patients with SR. Patients and methods: 20 patients with LI, 21 asymptomatic patients with SR and 21 healthy colunteers particpated in our study. In all participants cerebrovascular reactivity to Larginine was determined. In addition to blood flow velocity through both middle cerebral arteies, blood pressure, heart rate and CO2 in the exhaled air were monitored dilatation (FMD) of the brachial arteries, intima-media thickness (IMT) of the common carotid arteries and concentrazion of holesterol in blood were determined. We repeated all tests after 18 patients with LI and 20 asymptomatic patients with SR received 40 mg of artrovastatin daily for at least three months. 19 health colunteers did not receive any treatment. (Abstract truncated at 2000 characters) | |
| Descriptors | CEREBRAL INFARCTION ENDOTHELIUM, VASCULAR VASODILATION BRACHIAL ARTERY TUNICA INTIMA TUNICA MEDIA ARGININE CHOLESTEROL CEREBRAL ARTERIES ANTILIPEMIC AGENTS BLOOD PRESSURE HEART RATE CARBON DIOXIDE CAROTID ARTERY, COMMON BLOOD FLOW VELOCITY |