| Author/Editor | Potočnik, Marko | |
| Title | Okužba s humanim virusom papiloma v dlančnih mešičkih pri moških bolnikih z genitalnimi bradavicami | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2006 | |
| Volume | str. 123 | |
| Language | slo | |
| Abstract | Human papillomaviruses (HPV) are remarkably diverse DNA viruses that infect most mammals and birds and are causally involved in the etiology of different benign and malignant neoplastic lesions of mucosal and skin epithelium. HPVs are classified by the similarity of their genome into five genera and 27 species comprising currently 91 genotypes. Genital warts (GW) are the most common benign neoplastic lesions of the anogenital region, and are etiologically associated with the infection with HPV genotypes 6 and 11. Despite effective treatment, the recurrence of GW is very frequent. At present, it is not clear if the recurrence of GW is a result of a new infection with exogenous HPV or it is caused by HPVs from an endogenous reservoir in the surroundings of the removed GW. The aim of our study was to test the hypothesis that the hair follicles in the anogenital region might serve as important endogenous reservoir of HPVs responsible for reoccurrence of GW. The hypothesis was verified by a comparative study of the presence of HPV DNA in the eyebrow hairs and hair follicle samples plucked from three different sites in the genital region (pubic, scrotal and perianal) in 51 males with clinically evident GW, and in the control group. The control group comprised 51 patients with different dermatoses which were not caused by HPVs and were not sexually transmitted. According to the published data, this is the first comparative study of the prevalence of HPV infection in the hair follicle samples plucked from three different anogenital regions in the patients with clinically evident GW and in the hair follicle samples plucked from the same regions in healthy individuals. To date, only one similar study was performed, but it included a relatively small number of patients and no control group of hair follicle samples from healthy individuals. (Abstract truncated at 2000 characters) | |
| Descriptors | CONDYLOMATA ACUMINATA PAPILLOMAVIRUS, HUMAN DNA, VIRAL GENOTYPE HAIR FOLLICLE PREVALENCE EPIDERMODYSPLASIA VERRUCIFORMIS |