Author/Editor		Milivojevič, Nataša
Title		Vpliv ergolinskega derivata LEK-8829 na zasvojenost s kokainom pri podgani
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2006
Volume		str. 61
Language		slo
Abstract		One of the characteristics of cocaine addiction is the tendency for users to relapse, even after extended periods of drug abstinence. Guided by animal studies, various clinical treatments, designed to alleviate the principal symptoms of the cocaine abstinence syndrome, craving and anhedonia, have been tested, yet there is currently no effective pharmacotherapy for cocaine addiction. As the mesolimbic dopaminergic system is believed to represent the major neural substrate for the reinforcing effects of many addictive drugs, dopaminergic drugs are among the main candidate medications for the treatment of addiction. Studies performed on animal models of drug addiction show, that in contrast to their synergistic responses in most physiological and behavioural acrions, dopamine D1 and D2 receptors seem to have opposing effects on relapse to cocaine-seeking behaviour. While systemic injection of selective D2 agonists potentiates the ability of cocaine to induce cocaine-seeking and D2 agonists themselves induce cocaine-seeking behaviour, selective D1 agonists attenuate the ability of cocaine to induce cocaine-seeking behaviour and suppress the initiation of cocaine self-administration. These findings suggest that D2-like dopamine receptors could mediate the incentive for drug seeking and promote drug craving while D1-like dopamine receptors could mediate drug reward and gratification. A profile of D2 antagonist or D1 agonist drug thus seems to be promising for cocaine addiction treatment. The extinction and reinstatement paradigm of animal drug self-administration is considered as a model of human drug-craving and relapse. Many previous studies have focused mainly on the effects of selective D1 and D2 agonists and antagonists in animal models of cocaine addiction. To our knowledge a drug with combined D1 agonist and D2 antagonist properties has never been tested for the effects in animal models of drug addiction. (Abstract truncated at 2000 characters)
Descriptors		COCAINE SUBSTANCE DEPENDENCE ERGOLINES BEHAVIOR, ADDICTIVE RECURRENCE DISEASE MODELS, ANIMAL IN SITU HYBRIDIZATION CORPUS STRIATUM NEUROTENSIN ENKEPHALINS AUTORADIOGRAPHY OLIGONUCLEOTIDE PROBES SUBSTANCE P GENE EXPRESSION RATS, WISTAR