Author/Editor		Lainščak, Mitja; Doehner, Wolfram; Anker, Stefan D
Title		Metabolic disturbances in chronic heart failure: a case for the "macho" approach with testosterone?!
Type		članek
Source		Eur J Heart Fail
Vol. and No.		Letnik 9, št. 1
Publication year		2007
Volume		str. 2-3
Language		eng
Abstract		Chronic heart failure (CHF) primarily affects the cardiovascular system. In addition, there is strong evidence that CHF is a complex metabolic disorder. Metabolic abnormalities include insulin resistance and lack of anabolic hormone activity. To date there have been few interventional trials targeting insulin sensitivity. A recent study suggests a link between testosterone therapy and improvements in insulin sensitivity, measured using the homeostatic model assessment (HOMA-IR). We discuss this study in detail. Further studies are needed to substantiate this link and to generally explore the value of testosterone therapy in CHF patients.
Descriptors		HEART FAILURE, CONGESTIVE CACHEXIA TESTOSTERONE INSULIN RESISTANCE