Author/Editor		Predikaka, Marjana
Title		Pagetova bolezen - nenavadna pogostnost v koroški regiji
Translated title		Paget's disease - unusually high prevalence in the region of Koroška
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 75, št. 12
Publication year		2006
Volume		str. 861-3
Language		slo
Abstract		Paget's disease (PD) of bones is very common in the world, but uncommon in Slovenia. The cause of PD is still unknown, though 130 years ago the first description of the disease was published. Some genetic changes, viruses or toxic environmental influences, such as lead may play the role. In the region of Koroska (Carinthia) an unusually high prevalence of PD has been found. All patients live in the Upper Meziska Valley, which is known for its pollution with lead. Males are more affected, all patients have polyostotic form of PD with elevation of serum alkaline phosphatase, with a bone pain as their only complaint. Maybe lead from environment could be the reason for the high prevalence of PD in this region.
Summary		Pagetova bolezen (PB) kosti je ponekod po svetu pogosta, v Sloveniji pa je redka. Njena etiologija ni znana, čeprav je bila klinična slika prvič opisana že pred 130 leti. Kot možne vzroke navajajo genetske spremembe, viruse in škodljive snovi v okolju, med njimi tudi svinec. V Koroški regiji smo ugotovili veliko število bolnikov s PB. Bolniki večinoma živijo v Zgornji Mežiški dolini, kjer je okolje močno onesnaženo s svincem. Prevladujejo moški, vsi imajo poliostotično obliko to bolezni s povišano serumsko alkalno fosfatazo, edini simptom so bolečine v kosteh. Razlog za pogostejše pojavljanje PB v tej regiji je lahko večja prisotnost svinca v okolju.
Descriptors		OSTEITIS DEFORMANS ALKALINE PHOSPHATASE LEAD ENVIRONMENTAL EXPOSURE