Author/Editor		Wolf, P; Kripke, ML
Title		Photoimmunosuppression and sunscreens
Type		članek
Source		Acta Dermatovenerol Alp Panon Adriat
Vol. and No.		Letnik 1, št. 4
Publication year		1992
Volume		str. 103-8
Language		eng
Abstract		Exposure of skin to ultraviolet (UV) radiation induces suppression of immune responses to antigens applied after UV irradiation. This phenomenon, called photoimmunosuppression, is selective for cell-mediated immune responses and highly antigen specific. In mice, UV-induced immunosuppression contributes to the development of skin cancers. There is evidence that UV-induced alterations in immune function may also play a significant role in the development of skin cancers in humans. In addition, UV-induced immunosuppression may be an important factor in the pathogenesis of infectious diseases. Whereas sunscreens very effectively protect against some acute effects of UV radiation, they have limited immunoprotective abilities. Sunscreens are less protective against UV-induced immunologic alterations than against sunburn.
Descriptors		ULTRAVIOLET RAYS IMMUNOSUPPRESSION SUNSCREENING AGENTS SKIN DISEASES, INFECTIOUS SKIN NEOPLASMS