Author/Editor		Cerroni, L; Kerl, H
Title		Histological and immunohistochemical features of cutaneous T cell lymphomas
Type		članek
Source		Acta Dermatovenerol Alp Panon Adriat
Vol. and No.		Letnik 1, št. 1
Publication year		1992
Volume		str. 13-9
Language		eng
Abstract		Cutaneous T-cell lymphomas are malignant neoplasms of the immune system, characterized by a proliferation of neoplastic T lymphocytes within the skin. They comprise a very heterogeneous group of disorders with respect to clinical presentation, histomorphology, and prognosis. In this paper we classify T-cell lymphomas of the skin into two main groups according to the histopathological features, namely lymphomas of T-cell precursors and peripheral T-cell lymphomas (including Mycosis fungoides/Sezary-syndrome, T chronic Iymphocytic leukemia, T-pleomorphic, T-immunoblastic, and T-large cell anaplastic/ Ki1+lymphomas). In addition to histopathological classifcation, immunohistological examination allows a correct phenotypization of most T-cell lymphomas of the skin. This technique can be performed on routinely-fixed, paraffin-embedded tissue sections. Immunohistological features may help in differentiating malignant T-cell lymphomas from T-cell pseudolymphomas of the skin, and may provide additional prognostic criteria.
Descriptors		LYMPHOMA, T-CELL, CUTANEOUS IMMUNOHISTOCHEMISTRY LYMPHOMA, T-CELL, PERIPHERAL