Author/Editor		Vreča, I; Derganc, M; Grosek, Š
Title		Adenylate kinase activity in the cerebrospinal fluid of hypoxic newborns
Type		članek
Source		Clin Biochem
Vol. and No.		Letnik 22, št. 2
Publication year		1989
Volume		str. 135-9
Language		eng
Abstract		Adenylate kinase (AK) activity in the cerebrospinal fluid (CSF), described as a marker of brain edema and lesions in adults, was studied in 79 newborns with severe respiratory distress within 24 h after admission to the Intensive Care Unit (ICU). The CSF-AK activity was compared with CSF lactate concentration, CSF lactate dehydrogenase activity (LDH), and CSF and serum creatine kinase isoenzyme BB (CK-BB) activity. Newborns were divided into Group I with moderate to severe brain dysfunction and Group II with mild or no detectable brain dysfunction on discharge from the ICU. Mean CSF-AK activity (11.31 U/L) in Group I was significantly (p less than 0.001) higher than in Group II (2.82 U/L). Correlation between CSF-AK and CSF lactate was r = 0.714, p less than 0.01 and between CSF-AK activity and CSF-LDH activity was r = 0.550, p less than 0.01 in Group I. Preliminary data indicate that CSF-AK activity within 24 h after ischaemia is an indicator of hypoxic brain lesions in newborns. Its prognostic value for the infant's development remains to be determined by further study.
Descriptors		ASPHYXIA NEONATORUM INTENSIVE CARE UNITS, NEONATAL LACTATE DEHYDROGENASE CREATINE KINASE LACTATES ADENYLATE KINASE ENZYME TESTS INFANT, NEWBORN PHOSPHOTRANSFERASES