Author/Editor		Bevc, Sebastjan; Ekart, Robert; Hojs, Radovan
Title		Serumski cistatin C - nov označevalec glomerulne filtracije
Translated title		Serum cystatin C - a new marker of glomerular filtration rate
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 45, št. 3
Publication year		2006
Volume		str. 293-9
Language		slo
Abstract		The glomerular filtration rate (GFR) is the main indicator of kidney function and GFR estimation is essential for the evaluation of patients with chronic kidney disease. In clinical practice, serum creatinine levels and creatinine clearance are the most commonly used markers to estimate GFR. The standard GFR estimation method is based on the clearance of a radionuclide-labelled marker. Recently, serum cystatin C has been proposed as a new endogenous GFR marker. This protease inhibitor with a low molecular weight is produced at a constant rate by all nucleated cells and is freely filtered across the glomerular membrane. Contrary to serum creatinine, serum cystatin C does not depend on muscle mass, sex, age or dietary protein intake. This study confirmed that serum cystatin C is a reliable marker of GFR. Serum cystatin C had a higher diagnostic accuracy than serum creatinine and also creatinine clearance in well-defined patients with chronic kidney disease.
Summary		Glomerulna filtracija (GF) je najpomembnejši pokazatelj ledvične funkcije. Ocena GF je pomembna za obravnavo in spremljanje bolnika z ledvično boleznijo. V vsakdanji klinični praksi se za oceno GF najpogosteje uporabljata koncentracija serumskega kreatinina in očistek kreatinina, kot standardna referenčna metoda za določanje GF pa očistek radioizotopnega označevalca. V zadnjem času se kot eden novih označevalcev glomerulne filtracije pojavlja serumski cistatin C, inhibitor proteaz, ki v telesu nastaja stalno v vseh jedrnih celicah in se zaradi svoje majhnosti prosto filtrira v glomerulu. Za razliko od kreatinina koncentracija cistatina C ni odvisna od mišične mase, starosti, spola in načina ter vrste prehrane. Številne raziskave so potrdile, da je serumski cistatin C zelo dober označevalec GF. V določenih populacijah bolnikov z ledvično boleznijo se je koncentracija serumskega cistatina C pokazala kot boljši pokazatelj GF od koncentracije serumskega kreatinina.
Descriptors		KIDNEY DISEASES GLOMERULAR FILTRATION RATE CYSTATINS CREATININE