Author/Editor		Bren, Andrej; Kandus, Aljoša
Title		Mesto mikofenolata v nefrologiji
Translated title		Place of mycophenolate in nephrology
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 45, št. 3
Publication year		2006
Volume		str. 301-6
Language		slo
Abstract		The contribution focuses on one of the more recent immunosuppressive drugs, mycophenolate, which is available as mycophenolate mofetil and sodium mycophenolate. The active substance of both compounds is mycophenolic acid. The pharmacodynamics and pharmacokinetics of the active substance are presented. The broadest application of mycophenolate in nephrology is in kidney transplantation, which has resulted in less rejections of kidney grafts and better survival of grafts and patients. Limited success have been obtained in the treatment of some forms of lupus nephritis, systemic vasculitis, membranous nephropathy, focal and segmental glomerulosclerosis and glomerulonephritis with minimal changes, IgA nephropathy and acute interstitial nephritis.
Summary		V članku je prikazano novejše imunosupresivno zdravilo mikofenolat, ki je razpoložljivo kot mikofenolat mofetil in natrijeva sol mikofenolne kisline. Zdravilna učinkovina obeh spojin je mikofenolna kislina. Prikazani sta farmakodinamika in farmakokinetika zdravilne učinkovine. V nefrologiji je mikofenolat najpogosteje uporabljan pri presaditvi ledvic, saj omogoča manj zavrnitev, boljše preživetje presadkov in bolnikov. Z omejenimi uspehi se uporablja tudi pri zdravljenju nekaterih oblik lupusnega nefritisa, sistemskih vaskulitisov, membranske nefropatije, fokalne segmentne glomeruloskleroze in glomerulonefritisa z minimalnimi spremembami, IgA-nefropatije in akutnega intersticijskega nefritisa.
Descriptors		KIDNEY TRANSPLANTATION KIDNEY DISEASES MYCOPHENOLIC ACID LUPUS NEPHRITIS VASCULITIS GLOMERULONEPHRITIS IMMUNOSUPPRESSIVE AGENTS