Author/Editor		Glišovič, Špela; Glavan, Gordana; Saghafi, Mehdi M; Živin, Marko
Title		Upregulation of synaptotagmin IV protein in kainate-induced seizures
Type		članek
Source		NEUROREPORT
Vol. and No.		Letnik 18, št. 8
Publication year		2007
Volume		str. 831-5
Language		eng
Abstract		Synaptotagmin IV is a product of immediate early-responsegene.lt is involved in the regulated neurosecretion in the brain. Its putative role, however, in vesicular transport and localization in secretory vesicles is still a matterof debate. Here we followed the spatiotemporal pattern of synaptotagmin IV protein upregulation in the hippocampus, caudate putamen, nucleus accumbens, nucleus amygdalae, piriform and entorhinal cortices of rats with kainate-induced seizures. We found that upregulation pattern par alleled the direction of depolarization through the hippocampus and also reflecting seizure activity spreading to other brain regions. We speculate that synaptotagmin IV may have a role in the vesicular transport of the upregulated peptides and proteins involved in the plasticity and/or neurodegeneration provoked by the kainate.
Descriptors		SEIZURES KAINIC ACID BRAIN CHEMISTRY IMMUNOHISTOCHEMISTRY DENSITOMETRY SYNAPTOPHYSIN RATS, WISTAR UP-REGULATION (PHYSIOLOGY)