Author/Editor		Mahkovic-Hergouth, Ksenija
Title		Vpliv hipoalbuminemije na pojav pooperativnih komplikacij pri bolnikih, operiranih zaradi tumorja v trebuhu
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2006
Volume		str. 43
Language		slo
Abstract		Background. Hypoalbuminemia, which is most common in critical illness and after major surgery, has a bad prognostic value. Serum albumin concentration can rapidly decrease in acute illness or trauma due to increased vascular permeability and extravascular leakage of albumin, which is part of systemic inflammatory response syndrome. In the majority of the studies the replacement of albumin in hypoalbuminemic patients didn't influence postoperative morbidity and mortality, which reduced the use of expensive albumin solutions in the last years. However, there is no broad consensus on complete abandoning of the use of albumin. The purpose of our study was to fmd out, if there was a difference in postoperative complication rate when the patients had no albumin replacement, compared to those who did (before year 2000). We also looked for correlation between postoperative albumin concentration and some intraoperative parameters. Materials and methods. We retrospectively analysed patients after abdominal surgery, operated at Oncologic Institute in Ljubljana in year 1997/98 (group 1) and in year 2000/01 (group 2). The group 1 was given albumin solution if hypoalbuminemia was present, in the group 2 no albumins were used. Serum albumin and protein concentrations were compared in the first week after surgery (3 values) as well as the incidence of postoperative complication rate and the length of intensive care stay. We looked also for correlation between postoperative albumin concentration and duration of surgery, amount of transfusion and amount of infusion during surgery. (Results. 76 patients were included, 38 in each group which were comparable in age, ASA group, preoperative albumin concentration, duration of operation, amount of transfused red blood cells and amount of infusion during surgery. (Abstract truncated at 2000 characters)
Descriptors		ABDOMINAL NEOPLASMS HYPOPROTEINEMIA ALBUMINS POSTOPERATIVE COMPLICATIONS RISK FACTORS