Author/Editor		Zaletel, Katja
Title		Determinants of thyroid autoantibody production in Hashimoto's thyroiditis
Type		članek
Source		Expert review of clinical immunology
Vol. and No.		Letnik 3, št. 2
Publication year		2007
Volume		str. 217-23
Language		eng
Abstract		Hashimofo's fhyroiditis (HT) is the most prevalent thyroid autoimmune disorder, characterized by the presence of specific thyroid aufoantibodies (TAb). The development of autoimmunity, including TAb production and clinical presentation of HT, is determined by a complex interplay of genetic susceptibility and several endogenous and environmental factors, which are discussed in this article. During the progression of the disease, TAb production precedes clinical manifestations, although the correlation between TAb concentrations and thyroid function is weak. We do not treat euthyroid HT patients despite elevated TAb; while in hypothyroidism, replacement therapy with t-thyroxine is required. Until now, an effective approach To prevent TAb production and the development of clinical disease has not yet been established. However, further identification of risk factors and their interaction may help in the prevention of thyroid autoimmunity
Descriptors		THYROIDITIS, AUTOIMMUNE AUTOANTIBODIES