Author/Editor		Petrovec, Miroslav
Title		Okužbe z virusom varičela-zoster v nosečnosti
Translated title		Infection with varicella zoster virus in pregnancy
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 45, št. Suppl 3
Publication year		2006
Volume		str. 109-14
Language		slo
Abstract		Infection with varicella zoster virus during the first and second trimester of pregancy may lead to congenital varicella syndrome in newborn infant. Infection in the third trimester can result in life threatening pneumonia in pregnant women. Clinical varicella in the last week before and 2 days after delivery is a strong risk factor for severe neonatal varicella. In contrast to primary varicella, herpes zoster has not been linked to complications in the newborn. Urgent laboratory diagnostics is desired in the significantly exposed pregnant women to asses immunity to varicella. Varicella zoster immunoglobulin should be administered as soon as possible to prevent maternal infection and subsequent complications. Laboratory diagnostics should be performed in cases of clincal varicella or hepres zoster during pregnancy. Antiviral therapy is administered in maternal varicella with pneumonia and severely affected infant with neonatal varicella.
Summary		Okužba z virusom varicella-zoster v prvem in drugem trimesečju nosečnosti lahko vodi v nastanek kongenitalnega sindroma varičele pri novorojenčku. Okužba v tretjem trimesečju lahko pri nosečnici povzroči življenjsko nevarno pljučnico. Prebolevanje noric v zadnjem tednu pred porodom ali dva dni po porodu lahko pri otroku povzroči hudo klinično sliko noric. Pojav pasavca pri nosečnici za razliko od noric ni ogrožujoč za plod, razen kadar poteka v diseminirani obliki. Urgentna laboratorijska diagnostika znotraj 96 ur po izpostavitvi nosečnice je usmerjena predvsem v dokazovanje imunskega statusa, zaradi možne zaščite z imunoglobulini. Nujno je tudi potrjevanje diagnoze pri klinični sliki noric ali pasavca med nosečnostjo. Zdravljenje s protivirusnimi zdravili je primerno ob pojaw pljučnice pri nosečnici in pri zaradi noric hudo prizadetem novorojenčku.
Descriptors		PREGNANCY COMPLICATIONS, INFECTIOUS CHICKENPOX CHICKENPOX VACCINE HERPESVIRUS 3, HUMAN