Author/Editor		Kovačič, Uroš
Title		Vpliv nekaterih dejavnikov na kolateralno brstenje senzoričnih aksonov v živčno anastomozo konec s stranjo pri podgani
Translated title		Influence of some factors on collateral sprouting of sensory axons into end-to-side nerve anastomosis in the rat
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinjska fakulteta
Publication year		2007
Volume		str. 178
Language		slo
Abstract		Collateral sprouting is a process of multiple branching of intact axons of an uninjured peripheral nerve into a denervated target tissue abandoned by the injured nerve. Among the sensory axons in the skin of adult mammals' nociceptive axons A` display the greatest potential for collateral sprouting. Sensory and motor axons from an intact peripheral nerve can collaterally sprout also more proximally if the distal stump of a transected nerve is sutured to the side of an uninjured donor nerve (end-to-side nerve coaptation). The collateral sprouts of an uninjured donor nerve, growing through the endto-side nerve coaptation, can functionally reinnervate the denervated target tissue. The mechanisms of induction of collateral sprouting in the target tissue, as well as into the end to side coapted nerve, are not clear. The aim of the present work was to determine: 1) a possible role of the communication between the injured and uninjured neurons in the dorsal root ganglia (DRG) in induction of collateral sprouting, 2) the impact of the connective sheaths of the donor nerve on sprouting of sensory axons into the recipient nerve, 3) the long-term extent and stability of the connections made by the collateral sprouts from the donor nerve, 4) the effect of collateral spouting on the donor nerve itself, 5) the type of sensory axons, which are capable of sprouting into the end-to-side coapted nerve, 6) the impact of sex and age on collateral sprouting of sensory axons. We used the model of end-to-side nerve coaptaiion in the rat. The distal stump of the transected peroneal nerve was coapted to the side of the uninjured sural nerve, which is an almost pure sensory nerve. Young adult and aged rats of both sexes were used. The recovery of pain sensitivity in the skin of the dorsal foot was examined with the nociceptive skin pinch test. (Abstract truncated at 2000 characters)
Descriptors		PERONEAL NERVE NERVE DEGENERATION NERVE REGENERATION SURAL NERVE NOCICEPTORS RATS, WISTAR AXONS ACTION POTENTIALS NEURONS IMMUNOHISTOCHEMISTRY