Author/Editor     Trotovšek, B
Title     Histomorfološko odkrivanje onkogeneze v jetrih
Translated title     A histomorphological study of liver oncogenesis
Type     članek
Source     Med Razgl
Vol. and No.     Letnik 31, št. 2
Publication year     1992
Volume     str. 165-86
Language     slo
Abstract     Histomorphological changes occuring in the liver tissue were studied to confirm the hypothesis about sequential development of primary liver carcinoma. Tumor-surrounding liver tissue was evaluated in 27 cases of hepatocellular carcinoma and in 5 cases of cholangiocarcinorna in order to determine histomorphological and cytological characteristics of yet untransformed livertissue. These characteristics included low rate of HBV infections, high inflammation rate, cirrhosis and siderin overload. Small nodules forrned by round hepatocytes were observed in 62,5 per cent of cases. Cytological characteristics of these hepatocytes included morphological changes due to disturbances carbohydrate and protein metabolism, and slight nuclear changes. Preneoplastic histological alterations found in experimental hepatocarcinogenesis were similar to those observed in our study. Round, nodule-forming hepatocytes most likely represent a new, preneoplastic element in the liver parenchima. Further investigations will be needed to determine the significance of the above described changes.
Descriptors     LIVER NEOPLASMS
PRECANCEROUS CONDITIONS
LIVER CIRRHOSIS
ADENOMA
HEMOCHROMATOSIS
HEPATITIS B
ADULT
HEPATOMA
LIVER NEOPLASMS