| Author/Editor | Globočnik-Petrovič, Mojca | |
| Title | Vpliv genetskih in biokemičnih dejavnikov na napredovanje in zdravljenje diabetične retinopatije pri diabetesu tipa 2 | |
| Translated title | The influence of genetical and biochemical factors for the progression and treatment of diabetic retinopathy in type 2 diabetes | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2007 | |
| Volume | str. 116 | |
| Language | slo | |
| Abstract | Diabetic retinopathy (DR) is a complex multifactorial disease, which appears to be due to interaction of multiple genetic and environmental factors. The study of risk factors for DR enable us to understand the pathogenesis of DR. In the treatment of progressive forms of DR, proliferative DR (PDR), surgical methods such as vitrectomy are used. The success of vitrectomy is defined as postoperative visual acuity. In the last years the prognosis afrer vitrectomy is improving, but the outcome is still far from satisfactory. The success of vitrectomy depends on several factors, and the retinal ischemia is very important in this regard. In retrospective study 350 unrelated Caucasian subjects with type 2 diabetes were enrolled and divided into 2 groups: the DR (PDR, nonproliferative DR) and control group. The control group was represented by patients with the duration of type 2 diabetes of more than 10 years without diabetic retinopathy. The polymerase chain reaction was used to analyse several candidate genes - gene polymorphism for the receptor interleukin-1 antagonist, polymorphism G-174C for the interleukin -6 (IL-6), polymorphisms 553 T/A, -834 T/A and -921 C/G of the gene for beta fibroblast growth factor (BFGF), polymorphisms 634 C/G and -2549 insertion/deletion of the vascular endothelial growth factor (VEGF), polymorphism K469E of the intercellular adhesion molecule (ICAM), polymorphism Bgl II of the a2(31 integrin, polymorphisms -429 T/C and -374T/A of the receptor of advanced glycation end products (RAGE), mutations C282Y and H63D of the hemochromatosis, G482S polymorphism of the peroxisome proliferator-activated receptor-y coactivator-1 (PPARGCI) and polymorphism Prol2Ala of the PPARy. (Abstract truncated at 2000 characters) | |
| Descriptors | DIABETES MELLITUS, NON-INSULIN-DEPENDENT DIABETIC RETINOPATHY DISEASE PROGRESSION POLYMORPHISM (GENETICS) CYTOKINES RISK FACTORS ANGIOGENESIS FACTOR FLOW CYTOMETRY VITRECTOMY VISUAL ACUITY ENDOTHELIAL GROWTH FACTORS INTERLEUKIN-6 INTERLEUKIN-8 VITREOUS BODY |