Author/Editor		Trontelj, JV; Stalberg, E
Title		Jitter measurement by axonal microstimulation. Guidelines and technical notes
Type		članek
Source		Electroencephalogr Clin Neurophysiol
Vol. and No.		Letnik 85, št. 1
Publication year		1992
Volume		str. 30-7
Language		eng
Abstract		Single fiber EMG (SFEMG) with axonal micro-stimulation is a convenient method to study the neuromuscular jitter at the individual motor end-plates. Compared to the original method of jitter measurcment in voluntarily activated muscle, it has the advantage of perfect control of the discharge rate, including pauses in activity, useful in quantitative estimation of the neuromuxular transmission defect. It obviates the need to search for muscle fiber pairs. It can be used in young children and in uncooperative patients, as well as those with impaired voluntary motor control. It is useful in animal experiments as well as veterinary medicine. The technique eliminates the possibility of overestimating the jitter due to unrecognized interdischarge interval dependent jitter, as well as that of underestimating it due to unrecognized low jitter in split muscle fibers. The technique has eertain pitfalls causing under- or overestimation. The paper gives practical guidelines and hints as to how to avoid some of these, particularly errors due to overlooked threshold stimulation and to unrecognized direct muscle fiber stimulation.
Descriptors		NEUROMUSCULAR JUNCTION ELECTRIC STIMULATION MYASTHENIA GRAVIS ELECTROMYOGRAPHY NEURAL TRANSMISSION ACTION POTENTIALS AXONS MUSCLES REACTION TIME REFERENCE VALUES