Author/Editor		Kariž, Stojan; Milutinovič, Aleksandra; Bregar, Dejan; Terzić, Ibrahim; Terzić, Rifet; Lovrečić, Luca; Herova, Magdalena; Hruškovičova, Helena; Peterlin, Borut; Petrovič, Danijel; Zorc-Pleskovič, Ruda
Title		The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes
Type		članek
Source		Coll Antropol
Vol. and No.		Letnik 31, št. 2
Publication year		2007
Volume		str. 315-9
Language		eng
Abstract		In this study we investigated the association of the interleuhin-1 receptor antagonist gene variable number tandem repeat (ILIRNVNTR) polymorphism and of the inhibitor of kappa B-like protein (IKBL,) gene polymorphism with myocardial infarction (MI) in a group of patients with type 2 diabetes. The IL1RN VNTR and the IKBL+738T>C gene polymorphisms were tested in 374 Caucasians: 151 cases with MI and 223 subjects with no history of coronary artery disease. The ILIRN VNTR polymorphism was not a risk factor for MI an Caucasians with type 2 diabetes (genotype 22 vs. the rest: odds ratio (OR) 1.6; 95% confidence interval (CI) = 0.8-3.5; p=0.2). We also failed to demonstrate that IKBL+ 738T>C gene polymorphism was associated with MI an patients with type 2 diabetes (OR =0.9; 95% CI = 0.3-2.6; p=0.9). We provide evidence that the IL1RNVNTR and the IKBL+738T>Cgene polymorphisms are not risk factors for MI in Caucasians with type 2 diabetes.
Descriptors		MYOCARDIAL INFARCTION DIABETES MELLITUS, NON-INSULIN-DEPENDENT RECEPTORS, INTERLEUKIN-1 REPETITIVE SEQUENCES, NUCLEIC ACID ALLELES NF-KAPPA B POLYMORPHISM (GENETICS)