| Author/Editor | Urlep-Šalinović, Vera; Krajnc, Olga | |
| Title | Metabolični sindrom, protrombotično stanje in trombofilije pri otrocih | |
| Translated title | Metabolic syndrome, prothrombotic state and thrombophilia in children | |
| Type | članek | |
| Source | In: Gregorič A, editor. Metabolični sindrom pri otrocih, sodobni način življenja in imunski odziv pri otrocih, racionalna uporaba zdravil v pediatriji. Zbornik 17. srečanje pediatrov v Mariboru in 4. srečanje medicinskih sester; 2007 apr 13-14; Maribor. Maribor: Splošna bolnišnica Maribor, | |
| Publication year | 2007 | |
| Volume | str. 63-9 | |
| Language | slo | |
| Abstract | The metabolic syndrome is a constellation of risk factors of endogenous metabolic origin that are associated with the development of cardiovascular disease and type 2 diabetes. In adults, the metabolic syndrome is characterized by abdominal obesity, elevated triglycerides, reduced HDL cholesterol, elevated blood pressure and disturbed glucose and insulin metabolism. The same definition of MS is used in children and adolescents. Prothrombotic states in MS increase the risk of the development of arterial and venous thrombosis. Prothrombotic states arise because of abnormalities in coagulation and fibrinolysis, platelets and endothelial dysfunction. These abnormalities have been found in adults. However, such studies have not yet been performed in children. The thrombophilias are acquired and inherited haemostatic disorders increasing the risk of arterial and venous thromboembolism. In children thromboses are multitactorial and rare, occurring more frequently in neonates and adolescents. Acquired thrombophilic factors are associated with medical procedures and acute and chronic diseases. Of the inherited thrombophilic factors, the homozygous forms of antithrombin, protein C, protein S deficiency and homocystinuria are all associated with severe and extensive thrombosis and a high mortality. Other inherited thrombophilic factors (factor V G1691A, prothrombin G20210A, MTHFR C677T) usually cause thrombosis when other acquired thrombophilic factors are present. |