Author/Editor		Penko, Meta; Bevc, Sebastjan; Kanič, Vijko; Hojs, Radovan
Title		Prevalenca kronične ledvične bolezni pri bolnikih z akutnim koronarnim sindromom
Translated title		The prevalence of chronic kidney disease in patients with acute coronary syndrome
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 76, št. 3
Publication year		2007
Volume		str. 151-7
Language		slo
Abstract		Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GPR) is often estimated from serum creatinine. Recently several formulas, f or estimation of GFR have been developed. The most widely used are the Modification of Diet in Renal Disease (MDRD) Study equation and Cockcroft-Gault equation (C ` G). The prevalence of CKD is rising. The patients with CKD are at increased risk of cardiovascular disease. In ourstudy 449 patients (308 men and 141 women) with acute coronary syndrome and percutaneous coronary intervention were included. The average age was 63 years (SD +- 11.9). We collected blood samples for measuring serum concentrations of creatinine. The GFR was estimated using the MDRD Study equation and C and G equation. In our study women were statistically significantly older than men. 369 patients (82 %) had an acute myocardial infarction. The prevalence of CKD was 26.3 % when GFR was estimated by MDRD Study equation and 25.8% when GFR was estimated by C and G equation. Agreater prevalence of CKD was found in women and in patients older than 65 years old. Stages of CKD correlated with age and gender of the patients, with previously known ishemic heart disease and with diffuse coronary artery disease. In our study the prevalence of CKD in patients with acute coronary syndrome was high. CKD was an independent predictor for development of diffuse coronary artery disease.
Summary		Kronična ledvična bolezen (KLB) je vse večji zdravstveni problem svetovnih razsežnosti. Za oceno hitrostiglomerulne filtracije (GF) najpogosteje uporabljamo serumski kreatinin. V želji po natančnejši oceni KLB so v zadnjih desetletjih razvili več enačb za oceno GF Najbolj sta se uveljavili enačba raziskave Modification of Diet in Renal Disease (raziskava MDRD) ter Cockcroft-Gaultova enačba (C and G). Znano je, da prevalenca KLB v svetu narašča, bolniki s KLB so obremenjeni z večjim tveganjem za razvoj srčno-žilnih bolezni. V prospektivno raziskavo smo vključili 449 bolnikov (308 moških in 141 žensk), ki so bili zdravljeni v Splošni bolnišnici Maribor zaradi akutnega koronarnega sindroma. Povprečna starost bolnikov je bila 63 let (SD +- 11,9). Pri vseh bolnikih smo z urgentno invazivno srčno diagnostiko ocenili prizadetos tkoronarnih arterij. Vsem smo izmerili serumsko koncentracijo kreatinina, GF pa smo izračunali z enačbo raziskave MDRD in enačbo C and G. Med vključenimi bolniki smo ugotovili, da so bile ženske statistično značilno starejše. 369 bolnikov (82%) je prebolelo akutni miokardni infarkt. Prevalenca KlB po enačbi raziskave MDRD je znašala 263%, po enačbi C and G pa 25,8%. Ugotovili smo statistično značilno višjo prevalenco KLB pri ženskah in pri bolnikih, starejših od 65 let Ugotovili smo povezave med stopnjarni KLB in starostjo, spolom, znano ishemično boleznijo srca in difuzno prizadetostjo žil. V naši raziskavi smo ugotovili, da je prevalenca KLB pri bolnikih z akutnim koronarnim sindromom visoka. KLB je bila neodvisen napovedni dejavnik za razvoj difuzne koronarne arterijske bolezni.
Descriptors		KIDNEY FAILURE ANGINA, UNSTABLE MYOCARDIAL INFARCTION CORONARY DISEASE GLOMERULAR FILTRATION RATE CREATININE UREA TROPONIN PROSPECTIVE STUDIES