Author/Editor		Brožič, Petra; Gobec, Stanislav; Lanišnik-Rižner, Tea
Title		AKR1C1 and AKR1C3 as potential targets for phytoestrogen action
Type		članek
Source		In: Weiner H, Maser E, Lindahl R, et al, editors. Enzymology and molecular biology of carbonyl metabolism. Vol 13. Purdue: Purdue University,
Publication year		2007
Volume		str. 252-62
Language		eng
Abstract		AKR1C1 and AKR1C3 are members of the aldoketo reductase (AKR) superfamily and they act as pre-receptor regulatory enzymes. AKR1C1 funolions mainly as a 20alpha-hydroxysteroid dehydrogenase (HSD) and inactivates progesterone and the neuroactive 3a,5alpha-tetrahydroprogesterone, to form their less active counterparts, 20alpha-hydroxyprogesterone and 5alpha-pregnane-3alpha,20alpha-diol, respectively. AKR1C3 functions mainly as a 17beta-HSD and a 20alpha-HSD, and it reduces the weak androgen androstenedione to the potent androgen testosterone, it converts the weak estrogen estrone to the potent estrogen estradiol, and it inactivates the potent progesterone to form 20alpha-hydroxyprogesferone. Aberrant expression ofAKRICI and AKR1C3 can lead to the development of different hormone-dependent forms of cancers and other diseases. As the phytoestrogens have been correlated with lower incidence of several hormone-dependent forms of cancer, we have investigated their potential effects on the steroid metabolizing enzymes AKR1C1 and AKR1C3. (Abstract truncated at 2000 characters)
Descriptors		ALDEHYDE OXIDOREDUCTASES ENZYME INHIBITORS FLAVONES ESTROGENS