Author/Editor		Mušič, E; Šorli, J; Debeljak, A; Vizjak, A; Ferluga, D
Title		Verschiedene Charakteristika der exsudativen Pleuritis bei systemischem Erythematodes im Frueh- und Spaetstadium
Translated title		Different characteristics of early and later stage of exudative pleuritis in systemic erythematodes
Type		članek
Source		Atemwegs-Lungenkr
Vol. and No.		Letnik 17, št. 7
Publication year		1991
Volume		str. 315-9
Language		ger
Abstract		Different characteristics of early and later stage exsudative pleuritis in systemic erythematodes. According to the immunopatathogenesis of pleuritis in systemic erythematodes (SE) the pleural effusions and histologic patterns of pleura were evaluated in 12 cases of SE and in two cases also the immunohistology. Cytologic and immunologic differences were found between early stage of pleuritis, lasting for more than a week (group A, N = 5) and later stage of pleuritis, lasting for more than a week (group A, N = 7). In the early stage (A) cytologically the neutrophils (mean = 42 percent) and monohistiocytes (mean = 43 percent) while in the later stage the lymphocytes (mean = 68 percent) prevailed LE cells were found only in three cases of pleural effusion of the later stage. In the early and later stage greatly decreased or even absent complement (CH 50), C3 and C4 were found in pleural effusion. Antinuclear antibodies (ANA) were found in low titer in one case in the group A and in higher titer in all in the group B. In both groups the histologic pattern revealed nonspecific mononucleated cellular infiltration of pleura thus pleural biopsy was not diagnostic. Immunohistologic (IH) examination of pleural biopsy was performed in two cases of the group A: in one case IgM and C3 deposits and other one only C3 deposits in nuclei of mesothelial cells were found. According to our observations in the evaluation of cytologic and immunologic findings of pleural effusion in SE the "staging" of pleuritis should be considered since the findings are different in early and later stage of disease. IH may contribute to the diagnosis of SE pleuritis, while histology does not.
Descriptors		LUPUS ERYTHEMATOSUS, SYSTEMIC PLEURAL DISEASES PLEURAL EFFUSION IMMUNOHISTOCHEMISTRY