Author/Editor		Podnar, Simon
Title		Nevrofiziološka opredelitev delovanja perifernega živčevja pri maničnodepresivnih bolnikih, zdravljenih z litijem
Translated title		Neurophysiological assessment of peripheral nervous system function in manic-depressive patients, treated with lithium
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Mediciska fakulteta
Publication year		1992
Volume		str. 48
Language		slo
Abstract		Influence of lithium on peripheral nervous function was evaluated by comparing measurements of neurophysiological parameters in two groups of patients and a group of healthy volunteers. There were 20 lithium treated manic-depressive patients in the first group, 20 affective-psychotic patients without the lithium treatment in the second and 20 age and height matched healthy volunteers in the third. Motor system function was neurophysiologically assessed by measuring M wave amplitude after proximal and distal stimulation of the median and peroneal nerves, by calculating conduction velocity and by F wave latencies. Sensory system function of the median and sural nerves was assessed by measuring sensory conduction velocity and neurogram duration and amplitude. We found lower amplitudes of M waves on median neuve stimulation in both groups of patients (p < 0.015); M wave amplitudes on peroneal nerve stimulation were lower only in the group of lithium treated manic-depressive patients (p c 0.055). In sensory system only on median nerve stimulation amplitudes of neurograms were lower in both groups of patients comparing to healthy volunteers (p < 0.020). Our results show light pathological affection of motor and sensory axons in affective-psychotic patients, which is only a bit more severe in the lithium treated patients. This subclinical affection of peripheral nerves in manic-depressive patients is most likely due to several reasons, lithium (within therapeutic plasma concentrations) being just one.
Descriptors		BIPOLAR DISORDER LITHIUM PERIPHERAL NERVES MEDIAN NERVE PERONEAL NERVE NEURAL CONDUCTION