Author/Editor		Terčelj-Zorman, M; Mermolja, M; Jereb, M; Oman, M; Šooš, E; Petrič-Grabnar, G; Jereb, B
Title		Human leukocyte interferon alpha (HLI-alpha) for treatment of pleural effusion caused by non small cell lung cancer: a pilot study
Type		članek
Source		Acta Oncol
Vol. and No.		Letnik 30, št. 8
Publication year		1991
Volume		str. 232-4
Language		eng
Abstract		Fourteen patients with ipsilateral pleural effusion from non small cell cancer of the lung, 10 of them with generalized metastasis, were treated with local application of HLI-alpha in addition to other symptomatic treatment. Cytology of pleural Ruid at the beginning of treatment yielded cancer cells in all but one. HLI-alpha, 2 x 10**6 International Unita (I.U.) diluted in 20 ml of distilled water was injected intrapleurally each time. The mean survival of the HLI-a treated patients, measured from the first treatment of the pleural effusion, was 10.8 months. The performance status improved in 9 patients following HLl-alpha treatment. The pleural effusion eventually ceaned accumulating in all patients. To judge from cytology of tapped pleural, the cancer cells disappeared during treatment with HLI-alpha in patients.
Descriptors		CARCINOMA, NON-SMALL-CELL LUNG INTERFERON-ALPHA LUNG NEOPLASMS PLEURAL EFFUSION AGED CARCINOMA, NON-SMALL-CELL LUNG LUNG NEOPLASMS MIDDLE AGE PILOT PROJECTS PLEURAL EFFUSION