Author/Editor		Strle, F; Ružič, E; Cimperman, J
Title		Erythema migrans: comparison of treatment with azithromycin, doxycycline and phenoxymethylpenicillin
Type		članek
Source		J Antimicrob Chemother
Vol. and No.		Letnik 30, št. 4
Publication year		1992
Volume		str. 543-50
Language		eng
Abstract		Azithromycin, doxycycline and phenoxymethylpenicillin were compared in a prospective, randomized study of 64 patients with typical erythema migrans. Twenty patients were treated with oral azithromycin, 250 mg bd for two days followed by 250 mg od for eight days, 21 patients were given phenoxymethylpenicillin 1 million IU tds for 14 days and 23 patienls received doxycycline, 100 mg bd for I4 days. All patients were followed up for 24 months. There were no significant differences between the groups with respect to the persistence ofcutaneous lesions after starting treatment; the mean durations were IO-5 days in the penicillin group, 8-8 days in the doxycycline group and 8-6 days in the azithromycin group. There were statistically significant differences in terms of the resolulion of associated local and/or systemic symploms. The response lime was shortest in patients treated with azilhromycin. Two patients who received phenoxymethylpenicillin and two given doxycycline subsequently developed major manifestations of Lyme borreliosis; these did not occur in patienls receiving azithromycin. Although azithromycin has been shown to be effective in lhe treatmenl of erythema migrans, further studies will be needed to determinc the optimal dosage and duration of therapy.
Descriptors		ERYTHEMA CHRONICUM MIGRANS PENICILLIN V DOXYCYCLINE ERYTHROMYCIN PROSPECTIVE STUDIES ADULT ADOLESCENCE RANDOM ALLOCATION