Author/Editor		Stegnar, Mojca; Božic, Borut; Peternel, Polona; Kveder, Tanja; Vene, Nina; Rozman, Blaž
Title		Prevalence of antiphospholipid antibodies in deep vein thrombosis and their relationship to blood coagulation and fibrinolysis
Type		članek
Source		Thromb Res
Vol. and No.		Letnik 63, št. 4
Publication year		1991
Volume		str. 433-43
Language		eng
Abstract		Elevated levels of antiphospholipid antibodies are associated with an incteased risk of thrombosis. To establish the prevalence of these antibodies in deep vein thrombosis (DVT), IgG and IgM antibodies to cardiolipin (aCL) and phosphatidylserine (aPS) were determined by enzyme-linked immunosorbent assay in 118 patients with DVT either during an acute episode (N=53) or at least 2 months aftet acute DVT (N=65). Most patients (76 per cent ) had proximal leg DVT and no one had evident autoimmune disorder. aCL and aPS values highet than 4 standard deviations above the mean value of the control group ( 147 blood donors) were considered increased. Increased IgG aCL were observed in 10 per cent of DVT patients (controls: 5%, not significant), increased IgG aPS in 16 per cent of DVT patients (controls: 5 per cent , p less th. 0.005) and both types in 4 per cent of DVT patients (controls: 3 per cent , not significant). In the subgroup of 41 patients with previous idiopathic DVT, prevalence of increased IgG aPS was the highest: 27 per cent (p less th. 0.001). Inct,eased antibodies of IgM isotype were observed in 3 per cent (aCL) and 2 per cent (aPS) of all DVT patients (controls: 8 and 4 per cent , respectively, not significant). Elevated IgG aCL or aPS were not associated with significant changes in platelet count, antitrombin III and protein C. However, in patients with increased IgG aPS deficient fibrinolysis due to high plasminogen activator inhibitot activity was observed before and after 20 min upper arm venous occlusion. DVT patients with increased IgG aPS might be exposed to a greater risk of rethrombosis due to deficient fibrinolysis than DVT patients without these antibodies.
Descriptors		AUTOANTIBODIES BLOOD COAGULATION FIBRINOLYSIS PHOSPHOLIPIDS THROMBOPHLEBITIS LUPUS ERYTHEMATOSUS, SYSTEMIC MIDDLE AGE PHOSPHATIDYLSERINES REFERENCE VALUES THROMBOPHLEBITIS ADOLESCENCE ADULT BLOOD COAGULATION TESTS CARDIOLIPIDS ENZYME-LINKED IMMUNOSORBENT ASSAY IGG IGM