Author/Editor     van Delft, Joost HM; Kleinjans, Jos CS
Title     Predictive toxicogenomics for cancer risk assessment
Translated title     Napovedna toksikogenomika in ocena tveganja za nastanek raka
Type     članek
Source     Zdrav Vestn
Vol. and No.     Letnik 76, št. Suppl 2
Publication year     2007
Volume     str. II-25-6
Language     eng
Abstract     Every organism, and therefore also humans, is the product of its genes in combination with its environment. The activity of genes is strictly regulated and is continuously liable to changes. The response of an organism to changes in its environment, such as the exposure to a toxic substance, leads to altered gene expressions. Analysing modified gene expression profiles as a result of exposure to chemical substances, can therefore aid to determine the hazardous properties of those substances, such as on carcinogenic capacity. This toxicogenomics approach also provides the possibility to drastically reduce the traditional animal tests.
Summary     Vsak organizem, tudi človeški, je produkt delovanja lastnih genov v kombinaciji z dejavniki okolja. Aktivnost genov je strogo uravnavana in nenehno podvržena spremembam. Organizem se na spremembe v svojem okolju, na primer na izpostavljenost toksičnim snovem, odzove s spremembami v izražanju genov. Z analizo sprememb v izražanju genov, ki so posledica izpostavljenosti kemičnim snovem, lahko določamo škodljive učinke teh snovi, kot je npr. stopnja kancerogenosti. S takim toksikogenomskim pristopom lahko bistveno zmanjšmo uporabo tradicionalnih testov na živalih.
Descriptors     NEOPLASMS
RISK ASSESSMENT
DNA DAMAGE