Author/Editor | van Delft, Joost HM; Kleinjans, Jos CS | |
Title | Predictive toxicogenomics for cancer risk assessment | |
Translated title | Napovedna toksikogenomika in ocena tveganja za nastanek raka | |
Type | članek | |
Source | Zdrav Vestn | |
Vol. and No. | Letnik 76, št. Suppl 2 | |
Publication year | 2007 | |
Volume | str. II-25-6 | |
Language | eng | |
Abstract | Every organism, and therefore also humans, is the product of its genes in combination with its environment. The activity of genes is strictly regulated and is continuously liable to changes. The response of an organism to changes in its environment, such as the exposure to a toxic substance, leads to altered gene expressions. Analysing modified gene expression profiles as a result of exposure to chemical substances, can therefore aid to determine the hazardous properties of those substances, such as on carcinogenic capacity. This toxicogenomics approach also provides the possibility to drastically reduce the traditional animal tests. | |
Summary | Vsak organizem, tudi človeški, je produkt delovanja lastnih genov v kombinaciji z dejavniki okolja. Aktivnost genov je strogo uravnavana in nenehno podvržena spremembam. Organizem se na spremembe v svojem okolju, na primer na izpostavljenost toksičnim snovem, odzove s spremembami v izražanju genov. Z analizo sprememb v izražanju genov, ki so posledica izpostavljenosti kemičnim snovem, lahko določamo škodljive učinke teh snovi, kot je npr. stopnja kancerogenosti. S takim toksikogenomskim pristopom lahko bistveno zmanjšmo uporabo tradicionalnih testov na živalih. | |
Descriptors | NEOPLASMS RISK ASSESSMENT DNA DAMAGE |