Author/Editor		Globočnik-Petrovič, Mojca; Cilenšek, Ines; Petrovič, Daniel
Title		Manganese superoxide dismutase gene polymorphism (V16A) is associated with diabetic retinopathy in Slovene (Caucasians) type 2 diabetes patients
Type		članek
Source		Dis Markers
Vol. and No.		Letnik 24, št. 1
Publication year		2008
Volume		str. 59-64
Language		eng
Abstract		Substantial data indicate that oxidative stress is involved in the development of diabetic retinopathy. Two candidat genes that affect the oxidative stress are manganese mitochondrial superoxide dismutase (Mn-SOD) and endothelial nitric oxid Isynthase (eNOS). The aim of the present study was to examine the role of the V16A polymorphism of the Mn-SOD gene and th `a/b polymorphism of the eNOS gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes. 'In this cross sectional case-control study 426 unrelated Slovene subjects (Caucasians) with type 2 diabetes mellitus were enrolled 283 patients with diabetic retinopathy and the control group of 143 subjects with type 2 diabetes of duration of more than 1 ears who had no clinical signs of diabetic retinopathy. A significantly higher frequency of the VV genotype of the V16A polymorphism of the Mn-SOD was found in patients wit iabetic retinopathy compared to those without diabetic retinopathy (OR = 2.1, 95% CI = 1.2-3.4; p = 0.006), whereas the 4a/b polymorphism of the eNOS gene failed to yield an association with diabetic retinopathy. `4Ve may conclude that the V V genotype of the V 16A polymorphism of the Mn-SOD gene was associated with diabetic retinopathy in Caucasians with type 2 diabetes, therefore it might be used as a genetic marker of diabetic retinopathy in Caucasians.
Descriptors		REACTIVE OXYGEN SPECIES SUPEROXIDE DISMUTASE MANGANESE DIABETIC RETINOPATHY DIABETES MELLITUS, NON-INSULIN-DEPENDENT NITRIC-OXIDE SYNTHASE OXIDATIVE STRESS FUNDUS OCULI GENOTYPE POLYMORPHISM (GENETICS) CASE-CONTROL STUDIES