| Author/Editor | Zver, Samo; Zadnik, Vesna; Bunc, Matjaž; Rogel, Polona; Černelč, Peter; Koželj, Mirta | |
| Title | Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation | |
| Type | članek | |
| Source | Int J Hematol | |
| Vol. and No. | Letnik 85, št. 5 | |
| Publication year | 2007 | |
| Volume | str. 408-14 | |
| Language | eng | |
| Abstract | High-dose cyclophosphamide is a well-known mobilization regimen in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Highly differing rates of cardiac complications associated with high-dose cyclophosphamide have been reported. To date, no systematic clinical study has investigated high-dose cyclophosphamide mobilization regimens in multiple myeloma patients and evaluated its cardiotoxicity. We administered high-dose cyclophosphamide (4 g/m2) to 23 consecutive multiple myeloma patients and followed the patients for 15 days by serially measuring the cardiotoxicity biomarkers troponin I (TnI), brain natriuretic peptide (BNP), and endothelin 1 (ET-1). Systolic and diastolic left ventricular function was assessed by complete echocardiography before and at 6 to 8 weeks after the therapy. Patients younger than 55 years showed significant differences between basal TnI levels and TnI concentrations determined at 15 days after high-dose cyclophosphamide treatment (P = .028). Significant differences between basal BNP concentrations and BNP levels measured at 8 hours after high-dose cyclophosphamide treatment were found in the entire group of patients as well as in 2 subgroups, patients younger than 55 years and those older than 55 years (P <.0001, P <.001, and P = .001, respectively). ET-1 results for the entire group of patients showed a significant difference between baseline ET-1 values and ET-1 values determined 8 hours after high-dose cyclophosphamide administration (P = .004). Echocardiographic measurements revealed a barely nonsignificant decrease in cardiac output after high-dose cyclophosphamide infusion compared with pretreatment values (P = .06), a result in accord with echocardiographically detected increases in mild functional mitral regurgitation (P = .025). (Abstract truncated at 2000 characters) | |
| Descriptors | PLASMACYTOMA CYCLOPHOSPHAMIDE HEMATOPOIETIC STEM CELL TRANSPLANTATION TROPONIN I NATRIURETIC HORMONE ECHOCARDIOGRAPHY ENDOTHELIN-1 VENTRICULAR DYSFUNCTION, LEFT ELECTROCARDIOGRAPHY STROKE VOLUME |