Author/Editor     Avčin, Tadej; Toplak, Nataša
Title     Antiphospholipid antibodies in response to infection
Type     članek
Source     Curr Rheumatol Rep
Vol. and No.     Letnik 9, št. 3
Publication year     2007
Volume     str. 212-8
Language     eng
Abstract     An association between infections and antiphospholipid antibodies (aPL) has been reported in several epidemiologic and experimental studies. Infection-induced aPL have been traditionally regarded as transient and were generally not associated with clinical features of antiphospholipid syndrome. The distinction between autoimmune and postinfectious aPL on the basis of requirement of binding cofactor is not absolute, and in recent years, several reports demonstrated that some patients can produce pathogenic antibodies in response to infection. Infections most frequently associated with antiphospholipid syndrome include parvovirus B19, cytomegalovirus, varicella-zoster virus, HIV, streptococcal and staphylococcal infections, gram-negative bacteria, and Mycoplasma pneumoniae.
Descriptors     INFECTION
ANTIBODIES, ANTIPHOSPHOLIPID
VIRUS DISEASES
BACTERIAL INFECTIONS