Author/Editor		Kim, Man Deuk; Hoppe, Hanno; Pavčnik, Dušan; Kaufman, John A; Uchida, Barry T; Correa, Luiz O; Timmermans, Hans A; Park, Won Kyu; Corless, Christopher L; Keller, Frederick S; Rösch, Josef
Title		Percutaneous vein occlusion with small intestinal submucosa: an experimental pilot study in Swine and sheep
Type		članek
Source		Cardiovasc Intervent Radiol
Vol. and No.		Letnik 30, št. 4
Publication year		2007
Volume		str. 725-30
Language		eng
Abstract		Purpose: The objective of this study was to investigate the feasibility, outcomes, and amount of small intestinal submucosa (SIS) material needed for embolization of jugular vein (JV) in a swine and sheep model. Our hypothesis was that SIS would cause vein occlusion. Materials and methods: The external JVs (EJV) in swine (n = 6) and JVs in sheep (n = 6) were occluded with SIS fan-folded compressed strips. After percutaneous puncture of the peripheral portion of the EJV or JV, a TIPS set was used to exit their lumen centrally through the skin. The SIS strips were delivered into the isolated venous segment with a pull-through technique via a 10-Fr sheath. Follow-up venograms were done immediately after placement and at the time of sacrifice at 1 or 3 months. Gross examinations focused on the EJV or JV and their surrounding structures. Specimens were evaluated by histology. Results: SIS strip(s) placement was successful in all cases, with immediate vein occlusion seen in 23 of 24 veins (95.8%). All EJVs treated with two strips and all JVs treated with three or four strips remained closed on 1- and 3-month follow-up venograms. Two EJVs treated with one strip and one JV treated with two strips were partially patent on venograms at 1 and 3 months. There has been one skin inflammatory reaction. Necropsies revealed excluded EJV or JV segments with SIS incorporation into the vein wall. Histology demonstrated various stages of SIS remodeling with fibrocytes, fibroblasts, endothelial cells, capillaries, and inflammatory cells. Conclusion: We conclude that EJV and JV ablation with SIS strips using percutaneous exit catheterization is feasible and effective in animal models. Further exploration of SIS as vein ablation material is recommended.
Descriptors		INTESTINE, SMALL INTESTINAL MUCOSA JUGULAR VEINS EMBOLISM CATHETERIZATION, PERIPHERAL DISEASE MODELS, ANIMAL SWINE SHEEP